The AV booth at our church has four touchscreens that work fine except when the users try to touch different monitors at the same time. Timing is everything in audio/video live-streaming! We often have to wrap things multiple times because the other guy is doing something at the same instant.
PC (Windows 11) DisplayPort to monitor HDMI and USB to escort each monitor. In Asus 27” multitouch monitors connect with video.
I’m not sure if multi seat software is the only solution, but I’m thinking there will be more unforeseen issues if we go down that path.